The vast majority of Western medicine tablet particles must be objective, granulation, tablet, which is determined by the material properties. Made of particles, increase the flowability and compressibility. Compressible most simple measures were pressed into tablets pressure required for a certain hardness, if the required pressure is small, pressure may be applied, or, if the hardness is under certain pressure can be compressed into a compressed tablet hardness. The crude extract of some medicinal powder made of thick extract, mixing and granulating prescription medicines, another part of pulverizing herbs, two viscous mixture can be directly made of soft materials, the system of particles. After mixing, if viscous need adhesive or wetting granulation amount. A mixture of ropy should be things granulation too difficult, pressure test spots particles, medicinal powder, crude extract of pitting of drying, crushing into fine powder, add operation, moisturizing agent made of soft material particle system. Wider application of this method, suitable for most grains. Such as Yuanhuzhitong tablets, the bezoar antidotal tablet. The biggest advantage of this method is the thick extract powder in addition to have a certain therapeutic effect, thick extract from the binder, the powder pharmaceutical disintegrating agent, powder granulation and save attachments, simple operation.
Swing mechanism of particle particle specific purpose is as follows.
(1) increase the flow of materials: liquidity fine powder is poor, cannot smoothly from swinging into the die hole, hopper in the pellet machine less fluctuation, difference of tablet weight increased, but also the impact of tablets and granulation content increase liquidity. Medicinal powder the repose angle is usually about 65 degrees, generally about 45 degrees angle of repose of the particles, so the particle fluidity is good powder.
(2) reduced to a fine powder to reduce the adsorption and volume preservation air blade loose crack: fine powder is larger than the surface area, adsorption in the air in the storage content, when the punch is pressurized, powder in the air component cannot escape timely digital plate pressure, when the pressure is removed, the tablet, the internal air expansion crack caused by loose tablets.
(3) avoid the powder layer: the original accessories powder density prescription tablet several different types of process, due to vibration machine, sink so heavy, so that the light floating stratification is not allowed content.
(4) to avoid dust fine: fine dust, adhere to the surface of the punch or die wall, very easy to cause the sticking phenomenon |
The mechanism of rock particles grain what specific purpose?